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普罗地芬盐酸盐,Proadifen hydrochloride [SKF-525A];Calbiochem, ≥98% (TLC)

别名:N,N-二乙基氨基乙基 2,2-二苯基戊酸酯;α-苯基-α-丙基苯乙酸-2-(二乙氨)乙酯;α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester, SKF-525A, N,N-Diethylaminoethyl 2,2-diphenylvalerate

Empirical Formula (Hill Notation): C23H31NO2 · xHCl CAS号: 62-68-0 分子量: 353.50 (free base basis) MDL编号: MFCD00055151
货号(SKU): 567300
CAS号: 62-68-0
MDL号: MFCD00055151
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¥1,735.00

说明

Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

细胞渗透性。 阻断格列本脲敏感的 K+ 通道。 抑制神经元一氧化氮合酶。 还通过抑制细胞色素 P450 系统抑制肝脏药物代谢。

一般描述

Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.
Cell permeable. Blocks glibenclamide-sensitive K+ channels (IC50 = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.
 

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
nNOS
Target IC50: 90 µM against neuronal nitric oxide synthase
 

警告

Toxicity: Harmful (C)
 

重悬

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
 

其他说明

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

storage conditions

-20C

质量水平

100

测定

≥98% (TLC)

形式

solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 20 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

InChI key

FHIKZROVIDCMJA-UHFFFAOYSA-N

 

安全信息

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10