普罗地芬盐酸盐，Proadifen hydrochloride [SKF-525A]；Calbiochem, ≥98% (TLC)

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels (IC₅₀ = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.

 

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Primary Target
nNOS

Target IC₅₀: 90 µM against neuronal nitric oxide synthase

 

Toxicity: Harmful (C)

 

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

 

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

 

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