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抗体纯选蛋白A层析树脂,MabSelect PrismA protein A chromatography resin

Protein A层析树脂具有增强的碱性稳定性和结合能力,可提高抗体纯化过程的经济性。17549803;17549804;17549801;17549805;17549802
货号(SKU): 17549803
增值税发票 √ 免费送货 √ 订货电话:010-68689484
₹ 1,93,824.11

Protein A chromatography resin with enhanced alkaline stability and binding capacity for improved process economy in antibody purification.

MabSelect PrismA 亲和层析树脂采用优化的高流速琼脂糖基质和基因工程蛋白 A 衍生配体进行了改进。这可以满足未来对 mAb 纯化的需求,包括许多双特异性抗体的加工。

增强的动态结合容量可实现每树脂体积单位处理过的 mAb 的高质量通量。
出色的碱性稳定性可使用 0.5-1.0 M NaOH 进行高效清洁和消毒,从而提高工艺经济性、生物负载控制和稳健性。
涵盖全面的供应安全计划,包括琼脂糖基质和蛋白 A 配体的双重来源。
PrismA 蛋白 A 配体也可用于 HiTrap Fibro™ 和 HiScreen Fibro™ PrismA 色谱装置,用于 mAb 的超快速纯化。
MabSelect PrismA 增强的碱性稳定性还为使用定期逆流色谱法进行更稳健的 mAb 纯化提供了机会。使用 1 M NaOH 进行清洁的可能性增加了连续过程的生物负载控制,这些过程可能会暴露在数天或数周的饲料收获中。

 

MabSelect PrismA affinity chromatography resin has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein A-derived ligand. This allows future demands in mAb purification to be met, including processing of many bispecific antibodies.

  • Enhanced dynamic binding capacity allows high mass throughput of processed mAb per resin volume unit.
  • Excellent alkaline stability enables efficient cleaning and sanitization using 0.5–1.0 M NaOH for improved process economy, bioburden control, and robustness.
  • Covered by a comprehensive security of supply program, including dual sources of the agarose base matrix and protein A ligand.
  • The PrismA protein A ligand is also available in HiTrap Fibro™ and HiScreen Fibro™ PrismA chromatography units for ultrafast purification of mAbs.

The enhanced alkaline stability of MabSelect PrismA also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest.

For samples, contact your local sales representative or customer support.

MabSelect PrismA protein A resin builds on the proven track record of MabSelect and MabSelect SuRe resins in downstream processing of monoclonal antibodies.

Learn about ReadyToProcess MabSelect PrismA, prepacked HiScreen MabSelect PrismAHiTrap MabSelect PrismAPreDictor MabSelect PrismA or PreDictor Robocolumns MabSelect PrismA.

Learn how Bispecific antibodies (BsAb) can be purified using protein A chromatography in only a single step.

Learn about large scale column packing using MabSelect PrismA.

Learn about reducing bioburden and sanitization of MabSelect PrismA

 

ParameterMabSelect PrismA, 1 L
Chromatography techniqueAntibody affinity chromatography. 
BioProcess resinYes 
LigandAlkaline-stabilized protein A-derived (E.coli)
MatrixHighly cross-linked agarose, spherical. 
Particle Size60 µm 
Ligand Coupling MethodEpoxy 
Dynamic binding capacity, QB1080 mg human IgG/mL resin at 6 min residence time. 65 mg human IgG/mL resin at 4 min residence time. 
pH stability, operational3–12 
pH stability, CIP2–14 
Recommended maximum operational flow velocity300 cm/h 
Storage2˚C to 8˚C, 20% ethanol 
Chemical stabilityStable to commonly used aqueous buffers in protein A chromatography. 
Certificate of AnalysisYes 
Pack size1 L 
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16