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异泽兰黄素,Eupatilin;≥98% (HPLC)

别名:2-(3,4-二甲氧基苯基)-5,7-二羟基-6-甲氧基-4H-1-苯并吡喃-4-酮;5,7-二羟基-3',4',6-三甲氧基黄酮;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, NSC 122413, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone

Empirical Formula (Hill Notation): C18H16O7 CAS号: 22368-21-4 分子量: 344.32 MDL编号: MFCD13194819 PubChem化学物质编号: 329826018 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1689
CAS号: 22368-21-4
MDL号: MFCD13194819
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说明

异泽兰黄素已被用于体外研究其对颅内出血 (ICH) 诱导的炎症的抑制作用及其在小鼠 BV2 细胞中的抗炎机制。 它还被用作通过具有二极管阵列的微柱高效液相色谱 (HPLC-DAD) 测定法对蒿提取物进行定量评估的标准。

异泽兰黄素是艾蒿叶中的重要成分,也是 DA-9601 的活性成分。 它表现出抗凋亡作用。 异泽兰黄素在人脐静脉内皮细胞中提供针对肿瘤坏死因子 α (TNF-α) 介导的炎症的保护作用。 它用于治疗胃炎和消化性溃疡。 异泽兰黄素保护胃上皮细胞免受氧化损伤,保护平滑肌细胞免受吲哚美辛诱导的细胞损伤。 异泽兰黄素降低胆汁酸刺激的肝细胞凋亡。

异泽兰黄素是一种黄酮,具有抗氧化、抗炎和抗癌的特性。

应用

Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.
 

生化/生理作用

Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.
Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.
 
 

属性

质量水平

100

生物来源

(Isolated from Artemisia sp.)

测定

≥98% (HPLC)

形式

powder

储存条件

desiccated
protect from light

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES string

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31

InChI

1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3

InChI key

DRRWBCNQOKKKOL-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
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