小粒径离子交换层析树脂,Capto S ImpAct ion exchange chromatography resin

Capto S ImpAct 具有高结合容量和小粒径,是工业纯化过程中可靠和稳健的抛光步骤的理想选择。17371704;17371701;17371705;17371760;17371702;17371703
货号(SKU): 17371703
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With a high binding capacity and small particle size, Capto S ImpAct is a good choice for reliable and robust polishing steps in an industrial purification process.

Capto S ImpAct 具有高结合容量和小粒径,是工业纯化过程中可靠和稳健的抛光步骤的理想选择。

高结合容量,> 100 mg mAb/mL 树脂。
基于成熟的 Capto 平台的高分辨率抛光。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
这种层析树脂是我们基于 Capto 产品线的高分辨率树脂平台的一部分。聚合物配体与基础基质的特性相结合,使这种阳离子交换剂具有高结合能力。此外,小珠尺寸可实现高分辨率纯化。

Capto 树脂的高流动特性使其具有良好的压力流动特性。 Capto S ImpAct 的高结合容量和分辨率,结合在高流速和床高下运行的能力,提高了工艺设计的生产率和灵活性。

Capto S ImpAct 是一种 BioProcess 层析树脂,专为生物制药蛋白质的大规模纯化而开发。基于完善的 Capto 基础矩阵,它为提高生产力和简单的工艺开发提供了许多机会。

  • High binding capacity, > 100 mg mAb/mL resin.
  • Efficient aggregate removal at high load of monoclonal antibodies.
  • High-resolution polishing based on the well-established Capto platform.
  • Flexibility of design thanks to a large operational window of flow rates and bed heights for easy optimization and scaling.
  • High productivity enabling cost-efficient manufacturing.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Designed for large feed volumes

This chromatography resin is part of our platform of high-resolution resin based on the Capto product line. The polymeric ligand, in combination with the attributes of the base matrix, gives this cation exchanger a high binding capacity. Furthermore, the small bead size enables high-resolution purifications.

Able to run at high flow rates

The high-flow characteristics of Capto resin allow for good pressure-flow properties. The high binding capacity and resolution of Capto S ImpAct, combined with the ability to run at high flow rates and bed heights, increase productivity and flexibility in process design.

Suited to industrial scale applications

Capto S ImpAct is a BioProcess chromatography resin developed for large-scale purification of biopharmaceutical proteins. Based on the well-established Capto base matrix, it provides many opportunities for improved productivity and straightforward process development.

Prepacked columns and other formats

Capto S ImpAct resin is available in the following formats: 

Process development scale: prepacked

  • PreDictor Capto S ImpAct filter plates, 96-well plates for high-throughput screening or process development.
  • PreDictor Capto S ImpAct RoboColumn™ units, miniaturized columns for high-throughput process development.
  • HiScreen Capto S ImpAct columns, optimized for method and process development.

Lab scale: prepacked for manual purification

HiTrap Capto S ImpAct columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Lab scale: prepacked for automated purification and analysis

HiTrap Capto S ImpAct columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Process characterization: resin kits

Process Characterization Kit Capto S ImpAct, designed for studying the potential impact that resin ligand density might have on the process outcome.

Process-scale purification: prepacked

ReadyToProcess Capto S ImpAct columns,1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.


ParameterCapto S ImpAct, 1 L
Chromatography techniqueIon Exchange Chromatography 
BioProcess resinYes 
Particle size, d50V1~50 μm 
MatrixHigh-flow agarose 
Binding Capacity/ml Chromatography Medium>85 mg BSA/mL resin, >90 mg lysozyme/mL resin, >100 mg IgG/ mL resin 
Ionic Capacity37 to 63 umol (H+)/mL medium 
pH stability, operational24–12 
pH stability, CIP33–14 
Flow velocityAt least 220 cm/h in a 1 m diameter column with bed height 20 cm at 20°C; measured using process buffers with the same viscosity as water at < 3 bar (0.3 MPa) 
Storage0.2 M sodium acetate in 20% ethanol at 4°C to 30°C 
Estimated shelf life from manufacture date5 years 
Chemical stabilityCommonly used aqueous buffers, 1 M sodium hydroxide, 8 M urea, 6 M guanidine hydrochloride, 30% isopropanol and 70% ethanol 
Avoid UsingOxidizing agents, cationic detergent 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16