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奥贝胆酸,Obeticholic Acid [6-ECDCA];≥99% (HPLC)

别名:6-乙基鹅去氧胆酸;6-Ethylchenodeoxycholic acid;6alpha-Ethyl-chenodeoxycholic acid;6-Ecdca;6-Ethyl-cdca;C15636;6-Ethylchenodeoxycholic acid(Obeticholic Acid);Obeticholic Acid;(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid;(R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;Obeticholic acid 6-ECDCA;INT-747;1osv;CHC;INT747;UNII-0462Z4S4OZ

CAS:459789-99-2;分子式:C26H44O4;分子量:420.63
制造商品牌: BSZH 科学公司
货号(SKU): S06177
CAS号: 459789-99-2
MDL号: MFCD16621104
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$296.91

产品描述

本品可溶于DMSO(84mg/mL)

General description

一种胆酸的新衍生, 是FXR( 胆汁酸受体)激动剂,EC50:99nM。

Obeticholic Acid is a novel derivative of cholic acid which acts as a potent and selective FXR agonist displaying anticholeretic activity in an in vivo rat model of cholestasis. It inhibits vascular smooth muscle cell inflammation and migration as well as promotes adipocyte differentiation and regulates adipose cell function in vivo。

奥贝胆酸是胆酸的一种新型衍生物,在胆汁淤积症的体内大鼠模型中,它发挥有效的选择性FXR激动剂的作用,显示出抗胆汁的活性。 它可以抑制血管平滑肌细胞的炎症和迁移,并促进体内脂肪细胞的分化和调节脂肪细胞的功能。

Properties

Iupac Name(3alpha,5beta,6alpha,7alpha)-6-ethyl-3,7-dihydroxycholan-24-oic acid
Inchi Code1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
Inchi KeyZXERDUOLZKYMJM-ZWECCWDJSA-N


安全信息

风险声明 (欧洲) 23/24/25
安全声明 (欧洲) 26-36
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16