奥沙姆丁，Oxamflatin；≥98% (HPLC), solid

图片 奥沙姆丁，Oxamflatin；≥98% (HPLC), solid
别名：奥沙平；Metacept-3, HDAC抑制剂, 蛋白去乙酰化酶抑制剂；(2E)-5- [3-(苯磺酰基氨基)苯基]-戊-2-烯-4-氧异羟肟酸；(2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid

Empirical Formula (Hill Notation): C17H14N2O4S CAS号: 151720-43-3 分子量: 342.37 MDL编号: MFCD00949087 PubChem化学物质编号: 329818905 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: O3139
CAS号: 151720-43-3
MDL号: MFCD00949087
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说明

奥沙平是一种具有异羟肟酸基团的芳香族磺酰胺衍生物。它刺激转录因子JunD和纤连蛋白的表达。此外，奥沙莫坦还有助于各种NIH3T3衍生的转化细胞系的形态逆转。它在体外抑制各种小鼠和人类肿瘤细胞系的增殖。
组蛋白去乙酰化酶抑制剂;抗癌剂。

应用

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:
  • to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells[1]
  • to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation[2]
  • to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system[3]
  • to study its stand-alone effect on cytarabine-sensitive and resistant cells.[4]

生化/生理作用

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.[5]
Histone deacetylase inhibitor; anti-cancer agent.
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

溶解性

DMSO: soluble 13 mg/mL

储存温度

2-8°C

SMILES string

ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1

InChI

1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+

InChI key

QRPSQQUYPMFERG-LFYBBSHMSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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