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奥巴克拉,Obatoclax mesylate [GX 015070];≥99%(HPLC)

别名:(Z)-2-(2-(((3,5-二甲基-1H-吡咯-2-基)亚甲基)-3-甲氧基-2H-吡咯-5-基)-1H-吲哚甲磺酸盐;(Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate

MDL number MFCD18074508;Cas Number:803712-79-0;分子式:C21H23N3O4S;Molecular Weight : 413.5
制造商品牌: BSZH 科学公司
货号(SKU): G06054
CAS号: 803712-79-0
MDL号: MFCD18074508
增值税发票 √ 免费送货 √ 订货电话:010-68689484
HK$1,164.39

产品描述

Obatoclax mesylate(GX 015070)是一种BCL-2家族拮抗剂,Ki:220nM,可溶于DMSO(83mg/ml)

Biochem/physiol Actions

Obatoclax is a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon。

Obatoclax是bcl-2家族蛋白质的合成小分子抑制剂,具有潜在的促凋亡和抗肿瘤活性。 Obatoclax结合Bcl-2蛋白家族的成员,阻止这些抗凋亡蛋白与促凋亡蛋白Bax和Bak结合,从而促进Bcl-2过表达细胞中凋亡途径的激活。 Bcl-2蛋白家族蛋白(bcl-2,bcl-xl,bcl-w和Mcl-1)在多种癌症中过表达,包括淋巴系统癌,乳腺癌,肺癌,前列腺癌和结肠癌。

性质

Purity99%
Physical FormLight-red to Brown Solid
Iupac Name(2Z)-2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-5-(1H-indol-2-yl)-2H-pyrrol-3-yl methyl ether methanesulfonate
Inchi Code1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-;
Inchi KeyZFKXDVMHNXPEIY-PEZBNFGJSA-N


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 155 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 78 | 香港与北京 ≥ 32
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