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头孢噻肟钠盐 [噻孢霉素],Cefotaxime sodium salt;≥91% dry basis (HPLC)

别名:头孢霉素;头孢赛肟钠盐;头孢噻吩钠盐;Cefotaxim sodium salt;7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7²-(Z)-(O-methyloxime) Acetate, Na, Cefotaxim sodium salt

CAS号 64485-93-4 经验分子式(希尔表示法) C16H16N5NaO7S2 分子量 477.45 Beilstein/REAXYS Number 5711411 MDL number MFCD00079073
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 219380
CAS号: 64485-93-4
MDL号: MFCD00079073
增值税发票 √ 免费货运 [顺丰 联邦] √
¥2,986.41

产品描述

头孢噻肟钠盐, 属第三代头孢类抗生素

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis.

头孢菌素类抗β-内酰胺酶的强效抗生素。 对革兰氏阳性和革兰氏阴性生物(包括革兰氏阴性厌氧菌)具有活性。 抑制细胞壁合成。

General description

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis.

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against gram-positive and gram-negative organisms, including gram-negative anaerobes. Inhibits cell wall synthesis. Has an optimal pH of 4.5-6.5.

包装

2 g in Plastic ampoule

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Molinari, G., et al. 1991. J. Chemotherap. 3, 6.
Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother. 35, 2057.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 10 days at 4°C or for up to 13 weeks at -20°C.

性质

Quality Level100
assay≥91% dry basis (HPLC)
formcrystalline solid
optical activity[α]/D +58 to +64°, c = 1 in H2O
mfr. no.Calbiochem®
storage conditionOK to freeze
desiccated
protect from light
storage conditions+15C to +30C
colorwhite
solubilitywater: 250 mg/mL
shipped inambient
SMILES string[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI keyAZZMGZXNTDTSME-JUZDKLSSSA-M


安全信息

符号
GHS08  GHS08
信号词 Danger
危害声明 H317 - H334
警示性声明 P261 - P280 - P342 + P311
危害码 (欧洲) Xn
风险声明 (欧洲) 42/43
安全声明 (欧洲) 22-36/37
RIDADR NONH for all modes of transport
WGK德国 WGK 2
RTECS XI0250000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62