大黄酸，Rhein；≥98.0%

图片 大黄酸，Rhein；≥98.0%
别名: 1,8-二羟基-3-羧基蒽醌, 4,5-二羟基蒽醌-2-羧酸, 9,10-二氢-4,5-二羟基-9,10-二氧代-2-蒽羧酸, 大黄苷, 大黄酸, 山扁豆酸, 柯嗪3-羧酸； 4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow

Empirical Formula (Hill Notation): C15H8O6 CAS号: 478-43-3 分子量: 284.22 Beilstein: 2222155 EC 号: 207-521-4 MDL编号: MFCD00009618 PubChem化学物质编号: 24899390 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: R7269
CAS号: 478-43-3
MDL号: MFCD00009618
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说明

应用

Rhein has been used:
  • as a potassium simplex optimization medium with amino acids (KSOMaa) to induce degeneration in embryos to study its effect on the intracellular and extracellular micro-RNA (miRNA) signature[1]
  • as a fat mass and obesity-associated protein (FTO) inhibitor to study its role in motile ciliogenesis in an m6A-dependent manner in Xenopus embryos[2]
  • as an FTO inhibitor to infer its antiviral action in relation with the SARS-associated coronavirus 2 (SARS-CoV-2) infection[3]

生化/生理作用

Rhein, a cytotoxic agent, exhibits tumor suppression by activating apoptosis.[1] It is a selective inhibitor of demethylase fat mass and obesity-associated protein (FTO). Rhein is known to participate in various biological processes including obesity and adipogenesis.[3]
 
 

属性

质量水平

100

mp

≥300 °C (lit.)

储存温度

2-8°C

SMILES string

OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

InChI key

FCDLCPWAQCPTKC-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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