多粘菌素B硫酸盐，Polymyxin B sulfate salt；USP/NF, meets USP testing specifications, ≥6,000 USP units per mg

图片 多粘菌素B硫酸盐，Polymyxin B sulfate salt；USP/NF, meets USP testing specifications, ≥6,000 USP units per mg
别名：硫酸多粘菌素B；多黏菌素B硫酸盐；嗜气芽孢菌素； 阿罗多粘多胜菌素乙；阿如多粘；多粘菌素乙；Aerosporin; Polimixina B; Polimixina B [INN-Spanish]; Polymixin B; Polymyxine B; Polymyxine B [INN-French]; Polymyxinum B; Polymyxinum B [INN-Latin]; UNII-J2VZ07J96K

Empirical Formula (Hill Notation): C55H96N16O13 · 2H2SO4 CAS号: 1405-20-5 分子量: 1385.61 EC 号: 215-774-7 MDL编号: MFCD00131991 NACRES: NA.21
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: P0972
CAS号: 1405-20-5
MDL号: MFCD00131991
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说明

化学结构：肽
硫酸多粘菌素B是一种强阳离子环状多肽抗生素，来源于多粘菌杆菌的发酵。它是B1和B2硫酸盐的混合物。该产品已在临床上用于治疗由易感铜绿假单胞菌菌株引起的尿路、脑膜和血流感染。该产品还用于研究多药耐药病原体，作为去除内毒素的固定化试剂，并诱导切除的高粱根皮层细胞膜中的孔形成。

一般描述

Chemical structure: peptide
 

应用

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
 

生化/生理作用

作用方式：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。
 

包装

This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.
 

注意

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
 
 

属性

Agency

USP/NF
meets USP testing specifications

质量水平

200

形式

powder

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi

application(s)

pharmaceutical (small molecule)

作用机制

cell membrane | interferes

储存温度

2-8°C

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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