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多粘菌素B硫酸盐,Polymyxin B sulfate salt;BioReagent, suitable for cell culture, ≥6,000 USP units per mg

别名:硫酸多粘菌素B;多黏菌素B硫酸盐;嗜气芽孢菌素; 阿罗多粘多胜菌素乙;阿如多粘;多粘菌素乙;Aerosporin; Polimixina B; Polimixina B [INN-Spanish]; Polymixin B; Polymyxine B; Polymyxine B [INN-French]; Polymyxinum B; Polymyxinum B [INN-Latin]; UNII-J2VZ07J96K

CAS号 1405-20-5 经验分子式(希尔表示法) C55H96N16O13 · 2H2SO4 分子量 1385.61 EINECS 编号 215-774-7 MDL number MFCD00131991 NACRES NA.76
货号(SKU): P4932
CAS号: 1405-20-5
MDL号: MFCD00131991
增值税发票 √ 免费货运 [顺丰 联邦] √
¥543.00

产品描述

General description

Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.[2]
Chemical structure: peptide

Application

Polymyxin B sulfate salt has been used:
• for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor[3]
• as positive and negative control during microbicidal concentration (MCC) assay[1][4]

Biochem/physiol Actions

Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

作用方式:多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上,通过诱导足够大的孔来破坏细胞质膜,使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱:对大多数革兰氏阴性杆菌,包括 大肠杆菌 ,真菌和革兰氏阳性菌都有杀菌作用。

Caution

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Preparation Note

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

Other Notes

1mu,5mu

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

性质

Quality Level200
product lineBioReagent
formpowder
potency≥6,000 USP units per mg
application(s)cell culture | mammalian: suitable
solubilityH2O: 50 mg/mL
Mode of actioncell membrane | interferes
antibiotic activity spectrumGram-negative bacteria
storage temp.2-8°C
InChI1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI keyHNDFYNOVSOOGDU-UHFFFAOYSA-N


安全信息

个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS TR1150000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55