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培利替尼,Pelitinib;≥98% (HPLC)

别名:EKB-569, (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide, WAY-EKB-569, EKB 569

Empirical Formula (Hill Notation): C24H23ClFN5O2 CAS号: 257933-82-7 分子量: 467.92 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0197
CAS号: 257933-82-7
MDL号: MFCD09837868
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$292.50

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

Pelitinib (EKB-569) is an orally active, potent, second generation irreversible epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Pelitinib is selective for EGFR (ErbB-1) with an IC50 about 80 nM, but also covalently binds to ErbB-2 (HER2/c-neu) and ErbB-4 (Her 4) with much lower potency. Pelitinib has been shown to inhibit the growth of EGFR-overexpressing tumor cell lines.
 
Pelitinib (EKB-569) 是一种口服有效、有效的第二代不可逆表皮生长因子受体酪氨酸激酶 (EGFR TK) 抑制剂。 Pelitinib 对 EGFR (ErbB-1) 具有选择性,IC50 约为 80 nM,但也以低得多的效力与 ErbB-2 (HER2/c-neu) 和 ErbB-4 (Her 4) 共价结合。 Pelitinib 已被证明可以抑制过度表达 EGFR 的肿瘤细胞系的生长。
 

其他说明

Light sensitive
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

储存条件

desiccated
protect from light

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

−20°C

InChI

1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+

InChI key

WVUNYSQLFKLYNI-AATRIKPKSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

RIDADR

UN 2811 6.1 / PGIII

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16