sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

四环素盐酸盐 [盐酸四环素],Tetracycline hydrochloride;≥95% (European Pharmacopoeia HPLC assay)

Achromycin;Tetracyclin HCl;CAS号 64-75-5 经验分子式(希尔表示法) C22H24N2O8 · HCl 分子量 480.90 Beilstein/REAXYS Number 3844873 EINECS 编号 200-593-8 MDL number MFCD00078142 PubChem Substance ID 24900135 NACRES NA.76
货号(SKU): T3383
CAS号: 64-75-5
MDL号: MFCD00078142
增值税发票 √ 免费货运 [顺丰 联邦] √
¥684.00

产品描述

General description

Chemical structure: tetracycline

包装

25, 100 g in poly bottle

Application

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

Biochem/physiol Actions

作用机制:四环素通过细胞膜中的 proin 通道被动扩散,与 30S 核糖体结合,并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合,改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用,这表明起到抗菌作用的是可逆结合的抗生素,而不是不可逆结合的药物。

耐药性机制:这种作用通过细胞壁通透性的丧失而失活。

抗菌谱:包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

Caution

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

Preparation Note

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

性质

Quality Level200
assay≥95% (European Pharmacopoeia HPLC assay)
formpowder
coloryellow
mp220-223 °C (lit.)
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
storage temp.−20°C
SMILES stringCl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChI keyXMEVHPAGJVLHIG-FMZCEJRJSA-N


安全信息

符号
信号词 Warning
危害声明 H361d - H411
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26-36
RIDADR UN 3077 9 / PGIII
WGK德国 WGK 2
RTECS QI9100000
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55