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噻唑蓝,Thiazolyl Blue Tetrazolium Bromide [MTT];Calbiochem, ≥98% by HPLC

别名:MTT;噻唑兰;3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑噻唑蓝;噻唑蓝四唑蓝;噻唑四唑蓝溴化盐;3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide, Methylthiazolyldiphenyl-tetrazolium bromide

Empirical Formula (Hill Notation): C18H16BrN5S CAS号: 298-93-1 分子量: 414.32 MDL编号: MFCD00011964
货号(SKU): 475989
CAS号: 298-93-1
MDL号: MFCD00011964
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¥16,422

说明

可透过膜的黄色染料,在活细胞中被线粒体还原酶还原,形成深蓝色产物 MTT-甲臜。 在 540 或 570 nm 处对 MTT-甲臜进行分光光度测量,可以对细胞活力进行定量。 用作细胞毒性(如筛选抗癌药物)和细胞凋亡的直接指标。 用于研究 NADP 依赖性脱氢酶的电子受体。

一般描述

Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan. Spectrophotometric measurement of MTT-formazan at 540 or 570 nm allows quantitation of cell viability. Used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. An electron acceptor used for studying NADP-dependent dehydrogenases.
 

包装

1 g in Glass bottle
10 g in Plastic ampoule
 

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Used as a direct indicator of cytotoxicity and apoptosis.
 

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)
 

重悬

Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 1 month at -20°C.
 

其他说明

Liu, Y., et al. 1997. J. Neurochem.69, 581.
Abdallah, M.A. 1980. Eur. J. Biochem. 112, 331.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

storage conditions

+15C to +30C

 

安全信息

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16