哌立福新，Perifosine [KRX-0401]；≥98% (HPLC)

图片 哌立福新，Perifosine [KRX-0401]；≥98% (HPLC)
别名：4-[[羟基（十八烷氧基）亚膦基]氧基]-1,1-二甲基哌啶鎓内盐；十八烷基-（1,1-二甲基-4-哌啶基）磷酸酯；(1,1-二甲基哌啶-1--4-基)十八烷基磷酸酯；NSC 639966；D21266；4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium inner salt, KRX0401, Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

Empirical Formula (Hill Notation): C25H52NO4P CAS号: 157716-52-4 分子量: 461.66 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0612
CAS号: 157716-52-4
MDL号: MFCD00927554
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说明

应用

Perifosine has been used as an alkyl phospholipid AKT inhibitor.[1]
 

生化/生理作用

Perifosine (KRX-0401) is a selective bioavailable alkylphospholipid inhibitor of protein kinase B/Akt (PKB/Akt) with anti-proliferative activity. Perifosine acts on cell membranes, selectively targeting proliferating cells, inducing growth arrest and apoptosis.
Perifosine (octadecyl-(1,1-dimethyl-4-piperidylio)) is an antitumor compound. It acts at lipid rafts and stops lysosomal accumulation and mTORC1 (mammalian target of rapamycin complex 1) signaling.[1] This drug exhibits significant antiproliferative activity in vitro and in vivo in various human cancer model systems.[2]
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 10 mg/mL, clear

运输

wet ice

储存温度

−20°C

InChI

1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3

InChI key

SZFPYBIJACMNJV-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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