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咪唑,Imidazole;for molecular biology, ≥99% (titration), free-flowing, Redi-Dri™

别名:1,3-二氮杂-2,4-环戊二烯,甘恶啉,1,3-Diaza-2,4-cyclopentadiene, Glyoxaline

Empirical Formula (Hill Notation): C3H4N2 CAS号: 288-32-4 分子量: 68.08 Beilstein: 103853 MDL编号: MFCD00005183
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): RDD039
CAS号: 288-32-4
MDL号: MFCD00005183
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¥8,285.87

说明

咪唑是一种具有五元平面环的杂环化合物。它是两性的,极性很强。咪唑的药效团存在于包括氨基酸、植物生长调节剂和治疗剂在内的生物活性化合物中。
咪唑衍生物具有抗菌、抗真菌和抗癌功能。它与DNA相互作用,也与蛋白质结合并停止细胞分裂。它还充当微管失稳剂并抑制拓扑异构酶和细胞色素P450家族26亚家族a成员1(CYP26A1)酶。基于咪唑的抗癌药物在癌症化疗中得到应用。在固定化金属亲和层析(IMAC)中用作纯化组氨酸标记重组蛋白的缓冲组分。

一般描述

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.
 

应用

Imidazole has been used
  • in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein
  • in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography
  • as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
特别适用于 pH 6.2-7.8 范围内的缓冲液
 

生化/生理作用

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
 

法律信息

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
 
 

属性

等级

for molecular biology

质量水平

100

蒸汽压

<1 mmHg ( 20 °C)

产品线

Redi-Dri

测定

≥99% (titration)

形式

crystalline powder

质量

free-flowing

pH值(酸碱度)

6.2-7.8 (25 °C)

pKa (25 °C)

6.95

bp

256 °C (lit.)

mp

88-91 °C (lit.)

application(s)

diagnostic assay manufacturing

异质活性

DNase, RNase and protease, none detected

SMILES string

c1c[nH]cn1

InChI

1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)

InChI key

RAXXELZNTBOGNW-UHFFFAOYSA-N

 

安全信息

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(F)

293.0 °F - closed cup

闪点(C)

145 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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