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咖啡因，Caffeine；Pharmaceutical Secondary Standard; Certified Reference Material

咖啡因标准品；1,3,7-三甲基黄嘌呤；1,3,7-Trimethylxanthine；Empirical Formula (Hill Notation): C8H10N4O2 CAS号: 58-08-2 分子量: 194.19 Beilstein: 17705 MDL编号: MFCD00005758 PubChem化学物质编号: 329823040 NACRES: NA.24

制造商品牌: 色谱科 Supelco , 西格玛 Sigma-Aldrich

货号（SKU）: PHR1009

CAS号: 58-08-2

MDL号: MFCD00005758

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

¥2,618.75

数量:

说明

一般描述

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.[1]

应用

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations,[1] blood plasma,[2] food, drinks, and herbal products[3] by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

中枢神经系统兴奋剂，被认为通过腺苷受体和单胺类神经递质发挥作用。可作为腺苷受体拮抗剂和腺苷3′,5′-环单磷酸(cAMP)磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内cAMP的水平将升高。据报道，它会影响细胞钙水平，使细胞内的钙离子外流。它会使多种化学物质（例如蛋白酶抑制剂）的细胞周期效应无效，从而防止细胞凋亡；同时，还发现它可以抑制细胞的DNA修复机制。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 766
traceable to Ph. Eur. C0100000
traceable to USP 1085003

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

234-236.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

安全信息

象形图

GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P264 - P270 - P301 + P312 - P501

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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