sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

司他生坦钠,Sitaxentan sodium salt;≥98% (HPLC)

别名:N-(4-Chloro-3-methyl-5-isoxazolyl)-2-2-(6-methyl-1,3-benzodioxol-5-yl)acetyl-3-thiophenesulfonamide sodium salt, TBC-11251 sodium salt, Thelin, Sitaxsentan sodium salt

Empirical Formula (Hill Notation): C18H14ClN2NaO6S2 CAS号: 210421-74-2 分子量: 476.89 PubChem化学物质编号: 329823772 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0203
CAS号: 210421-74-2
MDL号: MFCD11040990
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$347.37

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR). Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 10 mg/mL (clear solution)

创始人

Pfizer

储存温度

room temp

SMILES string

Na+.Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)N-c4onc(C)c4Cl

InChI

1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1

InChI key

MDTNUYUCUYPIHE-UHFFFAOYSA-N

Gene Information

human ... EDNRA(1909), EDNRB(1910)

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10