司他生坦钠，Sitaxentan sodium salt；≥98% (HPLC)

图片 司他生坦钠，Sitaxentan sodium salt；≥98% (HPLC)
别名：N-(4-氯-3-甲基-5-异恶唑基)-2-[2-(6-甲基-1,3-苯并二氧杂环戊烯基)乙酰基]-3-噻吩磺酰胺钠盐；N-(4-Chloro-3-methyl-5-isoxazolyl)-2-2-(6-methyl-1,3-benzodioxol-5-yl)acetyl-3-thiophenesulfonamide sodium salt, TBC-11251 sodium salt, Thelin, Sitaxsentan sodium salt

Empirical Formula (Hill Notation): C18H14ClN2NaO6S2 CAS号: 210421-74-2 分子量: 476.89 PubChem化学物质编号: 329823772 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0203
CAS号: 210421-74-2
MDL号: MFCD11040990
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,850.00

说明

生化/生理作用

Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR).[1] Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).[2]
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 10 mg/mL (clear solution)

创始人

Pfizer

储存温度

room temp

SMILES string

Na+.Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)N-c4onc(C)c4Cl

InChI

1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1

InChI key

MDTNUYUCUYPIHE-UHFFFAOYSA-N

Gene Information

human ... EDNRA(1909), EDNRB(1910)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 10 | 欧洲Eur. ≥ 8 | 東京Tokyo ≥ 6 | 香港与北京 ≥ 60
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