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叔丁氧羰基五聚乙二醇乙酸,BocNH-PEG5-acid;liquid

别名:2,2-二甲基-4-氧代-3,8,11,14,17,20-六氧杂-5-氮杂二十烷-22-酸;2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid;Boc-NH-PEG5-CH2COOH

Empirical Formula (Hill Notation): C17H33NO9 CAS号: 890152-41-7 分子量: 395.45
制造商品牌: Sigma-Aldrich
货号(SKU): 902683
CAS号: 890152-41-7
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¥1,802.32

说明

应用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
 

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
 
 

属性

形式

liquid

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

官能团

Boc
amine
carboxylic acid

储存温度

−20°C

SMILES string

OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

 

安全信息

储存分类代码

10 - Combustible liquids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16