卡维地洛，Carvedilol；≥98% (HPLC), solid

图片 卡维地洛，Carvedilol；≥98% (HPLC), solid
别名：1-(9H-咔唑-4-氧基)-3-[2-(2-甲氧基苯氧基)乙基氨基]-2-丙醇；卡维地罗；1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol；BM-14190

Empirical Formula (Hill Notation): C24H26N2O4 CAS号: 72956-09-3 分子量: 406.47 MDL编号: MFCD00864692 PubChem化学物质编号: 329775050 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C3993
CAS号: 72956-09-3
MDL号: MFCD00864692
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

卡维地洛已被使用：

作为β阻滞剂，以确定其对缺氧诱导因子（HIF）介导的促红细胞生成的影响。
作为抑制条的βAR拮抗剂
作为一个β受体障碍者，在真菌挑战的小鼠中检查气道力学

卡维地洛是一种非选择性的β-肾上腺素能阻断剂，具有α1阻断活性。 卡维丝酚专门用于治疗心力衰竭和高血压。 已显示它可以改善左心室射血分数，并可能降低死亡率。

应用

Carvedilol has been used:
  • as a β blocker to determine its effect on hypoxia inducible factor (HIF)-mediated erythropoiesis under hypoxia in vivo
  • as a βAR antagonist for inhibition of bARs
  • as a β-blocker to examine airway mechanics in fungus-challenged mice

生化/生理作用

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.
 

特点和优势

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C3993.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

创始人

GlaxoSmithKline

SMILES string

COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChI key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

 

安全信息

象形图

Environment
GHS09

危险声明

H411

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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