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卡普瑞林酒石酸盐,Capromorelin tartrate;≥98% (HPLC)

别名:CP 424391-18, CP-424391 tartrate, 2-Amino-N-(1R)-2-(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo4,3-cpyridin-5-yl-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate

Empirical Formula (Hill Notation): C28H35N5O4 · C4H6O6 CAS号: 193273-69-7 分子量: 655.70 MDL编号: MFCD25977748 PubChem化学物质编号: 329823835
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0317
CAS号: 193273-69-7
MDL号: MFCD25977748
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$233.74

说明

Capromorelin tartrate 已在人体临床试验中用于治疗老年人虚弱。Capromorelin tartrate 是 GHSR1a (ghrelin) 受体的激动剂。 它与吡唑啉酮-哌啶二肽具有结构同源性。 Capromorelin tartrate 是一种有效的生长素释放肽受体激动剂/生长激素促分泌素 (Ki = 7 nM)。 在大鼠垂体细胞中,Capromorlelin 诱导生长激素 (GH) 分泌,EC50 为 3 nM。 Capromorelin 还可以增加胃动力,最近在脊髓损伤患者中进行了研究。

一般描述

Capromorelin tartrate has been used in human clinical trials as a treatment for frailty in elderly adults.
Capromorelin tartrate is an agonist of GHSR1a (ghrelin) receptors. It possesses structural homology with pyrazolinone-piperidine dipeptides.
 

包装

5, 25 mg in glass bottle

生化/生理作用

Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In rat pituitary cells, Capromorlelin incudes growth hormone (GH) secretion with an EC50 of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries.
 

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=C1N(C)N=C2CCN(C(C@H(NC(C(C)(C)N)=O)COCC3=CC=CC=C3)=O)CC@21CC4=CC=CC=C4.OC(C@H(O)C@@H(O)C(O)=O)=O

InChI

1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1

InChI key

MJGRJCMGMFLOET-MYPSAZMDSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16