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卡律蝎毒素,Charybdotoxin [CBTX];≥90% (HPLC)

卡律(布德)蝎毒素;在蝎子 Leiurus quinquestriatus 的毒液中发现的肽。
Empirical Formula (Hill Notation): C176H277N57O55S7;CAS号: 95751-30-7;分子量: 4295.89;MDL编号: MFCD00146378;NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C7802
CAS号: 95751-30-7
MDL号: MFCD00146378
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说明

Amino Acid Sequence

Glp-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser Disulfide Bridges: 7-28, 13-33, 17-35
 

应用

Charybdotoxin has been used:
  • in the inhibition of endothelium-derived hyperpolarizing factor responses
  • in electrophysiological studies, as calcium channel blockers
  • as a transport inhibitor

生化/生理作用

Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Charybdotoxin (ChTX) is a scorpion venom, which blocks a voltage-gated potassium channel, by binding to the extracellular loop of the potassium channel.
 

其他说明

Peptide found in the venom of the scorpion Leiurus quinquestriatus.
 

属性

质量水平

200

测定

≥90% (HPLC)

储存温度

−20°C

Gene Information

human ... KCNA3(3738)
mouse ... KCNA3(16491)
rat ... KCNA3(29731)

 

安全信息

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16