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华蟾素,Cinobufotalin;99%

别名:华蟾毒它灵;14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate, 5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate

Empirical Formula (Hill Notation): C26H34O7 CAS号: 1108-68-5 分子量: 458.54 MDL编号: MFCD28396383 PubChem化学物质编号: 24892362 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C1147
CAS号: 1108-68-5
MDL号: MFCD28396383
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说明

华蟾素是一种强心类固醇或蟾蜍灵。它主要从巨蟾的皮肤分泌物中获得。

华蟾素已用于:
作为标准,将它们与抗地高辛抗体 (Digibind) 的 Fab 片段结合,以通过地高辛的荧光偏振免疫测定快速检测其在血液中的存在
治疗人类癌细胞系/MCF-7 细胞以检查类固醇受体共激活因子 3 (SRC-3) 蛋白浓度并评估其作为 SRC 小分子抑制剂 (SMI) 的功效
作为校准高效液相色谱 (HPLC) 的标准,并计算存在于虎皮线虫颈腺液中的蟾蜍二烯内酯的总量

华蟾素是一种利尿剂和止血剂,可在培养的肺癌细胞中刺激细胞毒性作用。它可以抑制体内A549细胞的发育。华蟾素具有抗肿瘤活性和增强的化学治疗作用。它可以抑制血管内皮生长因子和表皮生长因子受体的表达,从而阻止肿瘤的发展和转移。推进胃癌 (GC) 患者可能是有益的。这种安全的辅助抗肿瘤剂可以减少与化疗相关的不良事件。

一般描述

Cinobufotalin is a cardiotonic steroid or bufotalin. It is mainly obtained from the skin secretion of the giant toad.
 

应用

Cinobufotalin has been used:
  • as a standard to bound them with the Fab fragment of an anti-digoxin antibody (Digibind) to rapidly detect its presence in blood by the fluorescence polarization immunoassay for digitoxin
  • to treat human cancer cell lines/MCF-7 cells to examine the steroid receptor coactivator-3 (SRC-3) protein concentrations and evaluate its efficacy as SRC small-molecule inhibitors (SMIs)
  • as a standard to calibrate the high-performance liquid chromatography (HPLC) and calculate the total quantity of bufadienolides present in the nuchal gland fluid of Rhabdophis tigrinus
 

生化/生理作用

Cinobufotalin, a diuretic, and a hemostatic agent can stimulate cytotoxic effect in cultured lung cancer cells. It can suppress the development of A549 cells in vivo. Cinobufotalin possesses antitumor activity and enhanced chemotherapeutic effect. It can inhibit the vascular endothelial growth factor and epidermal growth factor receptor expression to prevent the development and metastasis of the tumor. It may be beneficial to advance gastric cancer (GC) patients. This safe auxiliary antitumor agent can reduce the adverse events related to chemotherapy.
 
 

属性

质量水平

200

形式

solid

储存温度

2-8°C

SMILES string

C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]35O[C@@H]5[C@H](OC(C)=O)[C@@H]4C6=COC(C=C6)=O)(O)C[C@@H](O)CC1

InChI

1S/C26H34O7/c1-14(27)32-21-20(15-4-5-19(29)31-13-15)24(3)10-7-17-18(26(24)22(21)33-26)8-11-25(30)12-16(28)6-9-23(17,25)2/h4-5,13,16-18,20-22,28,30H,6-12H2,1-3H3/t16-,17-,18+,20-,21+,22+,23+,24+,25-,26+/m0/s1

InChI key

KBKUJJFDSHBPPA-ZNCGZLKOSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
商品标签 [tags]