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匹伐他汀钙,Pitavastatin calcium;≥98% (HPLC)

别名:伊伐他汀;(+)monocalcium bis{(3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5dihydroxy-6-heptenoate}, (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid calcium salt

CAS号 147526-32-7 经验分子式(希尔表示法) C25H23FNO4 · 0.5Ca 分子量 440.49
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2473
CAS号: 147526-32-7
MDL号: MFCD01937979
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$106.11

产品描述

一种有效的HMG-CoA还原酶抑制剂。

Biochem/physiol Actions

Pitavastatin calcium is a water-soluble inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Pitavastatin calcium is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

匹伐他汀钙是羟甲基戊二酰辅酶A(HMG-CoA)还原酶的水溶性抑制剂,该酶催化HMG-CoA转化为甲羟戊酸,这是胆固醇生物合成中的限速步骤。 匹伐他汀钙具有抗血脂作用,可用于降低血浆胆固醇水平并预防心血管疾病。

性质

assay  ≥98% (HPLC)
form  powder
optical activity  [α]/D +19 to +24°, c = 1 in acetonitrile: water (1:1)
storage condition  desiccated
color  white to beige
solubility  DMSO: 2 mg/mL, clear
storage temp.  2-8°C
InChI  1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1
InChI key  RHGYHLPFVJEAOC-FFNUKLMVSA-L


安全信息

符号 
GHS08  GHS08
信号词 Warning
危害声明 H361f
警示性声明 P201 - P308 + P313
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32