制霉菌素，Nystatin；≥4,400 USP units/mg

图片 制霉菌素，Nystatin；≥4,400 USP units/mg
别名：一种多烯型抗生素；米可定；制霉素；制霉菌素；Nystatin, Fungicidin, Mycostatin

CAS号: 1400-61-9 EC 号: 215-749-0 MDL编号: MFCD25541651 PubChem化学物质编号: 24897647 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: N3503
CAS号: 1400-61-9
MDL号: MFCD25541651
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¥750.00

说明

制霉菌素是一种多烯类抗生素。
化学结构：多烯
制霉菌素被用作真菌膜（麦角固醇结合）成孔剂，并在脂质双层中创建基于制霉菌素/麦角固醇的离子通道。其用途包括防止细胞培养物污染，诱导表达TLR2的THP1细胞分泌白介素（IL）-1、IL-8和肿瘤坏死因子α。本产品推荐用于50 mg/L的细胞培养应用。

一般描述

Nystatin is a polyene antibiotic.
Chemical structure: polyene
 

应用

Nystatin is used as a fungal membrane (ergosterol binding) pore forming agent and to create nystatin/ergosterol based ion channels in lipid bilayers. Its uses include preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor α secretion in TLR2-expressing THP1 cells. This product is recommended for use in cell culture applications at 50 mg/L.
 

生化/生理作用

作用机制：制霉菌素通过与真菌细胞膜中的麦角甾醇结合，增加膜的渗透性和产生基于制霉菌素/麦角甾醇的离子通道起作用。 它还可作为脂筏抑制剂和膜相关胆固醇。

抗菌谱：制霉菌素可对抗真菌、酵母和霉菌。
 

注意

Nystatin in tissue culture media is stable at 37°C for three days. It is also stable in moderately alkaline media. Solutions and aqueous suspensions begin to lose activity soon after preparation, with heat, light, and oxygen accelerating the decomposition. Aqueous suspensions are stable for 10 minutes when heating to 100°C at pH 7.
 

制备说明

Nystatin is soluble at 28°C in methanol (11.2 mg/mL), ethanol (1.2 mg/mL), carbon tetrachloride (1.23 mg/mL), chloroform (0.48 mg/mL), benzene (0.28 mg/mL), and ethylene glycol (8.75 mg/mL). It is also soluble in DMSO at 5 mg/mL and freely soluble in DMF and formamide. It is not recommended to autoclave or sterile filter solutions of Nystatin. Prepare 50 mg/mL stock suspensions in water and store at -20°C.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Air and light sensitive.
 
 

属性

形式

powder

质量水平

200

specific activity

≥4,400 USP units/mg

溶解性

water: insoluble

抗生素抗菌谱

Gram-positive bacteria
fungi
yeast

作用机制

cell membrane | interferes

储存温度

−20°C

SMILES string

O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

 

安全信息

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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