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利巴韦林，Ribavirin；Pharmaceutical Secondary Standard; Certified Reference Material

别名：利巴韦林标准品；病毒唑；1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺；1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide；1-β-D-呋喃核糖-1,2,4-三氮唑-3-羟酰胺；三氮唑核苷; 1-beta-D-呋喃核糖基-1H-1,2,4,-三氮唑-3-羧酰胺；三唑核苷；病毒唑；威乐星

Empirical Formula (Hill Notation): C8H12N4O5 CAS号: 36791-04-5 分子量: 244.20 MDL编号: MFCD00058564 PubChem化学物质编号: 329823563

制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco

货号（SKU）: 555580

CAS号: 36791-04-5

MDL号: MFCD00058564

增值税发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

¥1,655.11

数量:

说明

利巴韦林是一种合成鸟苷类似物，对呼吸道合胞病毒、几种出血热病毒和人类免疫缺陷病毒有效。
利巴韦林可用作通过高压液相色谱法测定药物剂型中分析物的药物参考标准。
这些二级标准被认定为合格参考材料。这些适用于多种分析应用，包括但不限于药物释放测试、用于定性和定量分析的药物方法开发、食品和饮料质量控制测试以及其他校准要求。

一般描述

嘌呤核苷酸生物合成中咪唑核苷酸中间体的类似物。

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.

应用

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

用于抵御多种人类病毒感染的抗病毒剂，特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸，是肌苷一磷酸 (IMP) 脱氢酶的抑制剂，但也有实验证据支持许多其他作用机制。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 593
traceable to Ph. Eur.
traceable to USP 1602706

CofA

current certificate can be downloaded

包装

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

InChI key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

Gene Information

human ... IMPDH1(3614)

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H341 - H360FD

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Muta. 2 - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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