假尿苷，Pseudouridine；≥98%

伪尿苷是一种C-糖基嘧啶，由尿嘧啶组成，尿嘧啶在位置5处连接有β-D-呋喃呋喃糖基残基。嘧啶核苷尿苷的C-糖基异构体。它具有基本代谢物的作用。假尿苷存在于除mRNA以外的所有物种和所有类别的RNA中。它由称为假尿苷合酶的酶形成，该酶在转录后异构化RNA中的特定尿苷残基。

Pseudouridine (Ψ) stands as an isomer of the nucleoside uridine, featuring a carbon-carbon bond instead of the typical nitrogen-carbon glycosidic bond connecting uracil. It represents the most prevalent among the myriad modified nucleosides within RNA, with a presence spanning various species and RNA classes. The enzymatic action of Ψ synthases induces post-transcriptional isomerization of specific uridine residues, a process known as pseudouridylation. This modification, particularly in rRNA and tRNA, plays a vital role in fine-tuning and stabilizing regional structures, contributing to mRNA decoding, ribosome assembly, processing, and translation functions. Moreover, β-pseudouridine, identified in tRNAs across bacteria, archaea, and eukaryotes, has demonstrated potential in reducing radiation-induced chromosome aberrations in human lymphocytes. Its utility as a cancer and proliferation biomarker positions it as a valuable asset in metabolomics and biochemical research.

 

Pseudouridine is a versatile compound and a biomarker that finds application in metabolomics and biochemical research.

 

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