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倍他米松，Betamethasone；Pharmaceutical Secondary Standard; Certified Reference Material

别名：β-类松；正妥；9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮；9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮；9α-氟-16β-甲基泼尼松龙；9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone

Empirical Formula (Hill Notation): C22H29FO5 CAS号: 378-44-9 分子量: 392.46 EC 号: 206-825-4 MDL编号: MFCD00062969 PubChem化学物质编号: 329823372

制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco

货号（SKU）: PHR1398

CAS号: 378-44-9

MDL号: MFCD00062969

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

¥1,273.00

数量:

说明

倍他米松属于活性药物成分（API）的皮质激素家族。它具有抗炎活性，因此可用于制造各种成品药物，也可用作制造与该类固醇家族相关的其他API的原料。
倍他米松可用作药物参考标准，用于通过使用胶束液相色谱技术和反相高效液相色谱技术定量药物制剂中的分析物。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Betamethasone belongs to the corticosteriod family of active pharmaceutical ingredients (APIs). It exhibits anti-inflammatory activity and hence is used in the manufacture of various finished pharmaceutical products and is also employed as a starting material to manufacture other APIs that are related to this steroid family.

应用

Betamethasone may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations by using micellar liquid chromatography technique and reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2174 in the slot below. This is an example certificate only and may not be the lot that you receive.

属性

生物来源

synthetic

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

Agency

BP
EP
USP
traceable to BP 575
traceable to Ph. Eur. B1000000
traceable to USP 1066009

蒸汽压

<0.0000001 kPa ( 25 °C)

CofA

current certificate can be downloaded

包装

pkg of 1 g

储存条件

protect from light (20 mm aluminium crimp seal for unused portion)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

颜色

white to light yellow

mp

235-237 °C (lit.)

溶解性

acetone: sparingly soluble
chloroform: very slightly soluble
ethanol: sparingly soluble
ether: very slightly soluble
methanol: sparingly soluble
water: insoluble

密度

0.305 g/cm³ at 25 °C (77°F)

application(s)

pharmaceutical (small molecule)

格式

neat

运输

ambient

储存温度

2-30°C

SMILES string

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

Gene Information

human ... NR3C1(2908)

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H360FD - H373

预防措施声明

P202 - P260 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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