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伯舒替尼,Bosutinib;≥98% (HPLC)

别名:SKI-606, 4-(2,4-Dichloro-5-methoxyphenyl)amino-6-methoxy-7-3-(4-methyl-1-piperazinyl)propoxy-3-quinolinecarbonitrile, WAY-173606

Empirical Formula (Hill Notation): C26H29Cl2N5O3 CAS号: 380843-75-4 分子量: 530.45 MDL编号: MFCD07367846 PubChem化学物质编号: 329823766 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0192
CAS号: 380843-75-4
MDL号: MFCD07367846
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$261.09

说明

博舒替尼是一种安全的口服药物,具有良好的生物利用度。 它对治疗慢性粒细胞白血病(CML)有效。 它也是 Src 酪氨酸激酶的有效 ATP 竞争性抑制剂。 博舒替尼抑制表皮生长因子受体 (EGFR)。 它抑制与乳腺、胰腺和前列腺相关的实体瘤。Bosutinib (SKI-606) 是一种口服活性剂; 双重 Src/Abl 酪氨酸激酶抑制剂,具有有效的抗增殖活性。 它似乎不抑制 c-Kit 和 PDGRF,这被认为是在使用其他一些酪氨酸激酶抑制剂进行抗癌治疗时产生许多副作用的原因。

 

一般描述

Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML). It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate.
 

包装

5 mg in glass bottle
 

生化/生理作用

Bosutinib (SKI-606) is an orally active; dual Src/Abl tyrosine kinase inhibitor with potent antiproliferative activity. It does not appear to inhibit c-Kit and PDGRF, which are thought to be the cause of numerous side effects in anticancer treatment with some other tyrosine kinase inhibitors.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

Sigma-Aldrich is a licensed supplier of Bosutinib, providing the authentic Pfizer compound. The material is independently assayed and verified by both Pfizer and Sigma-Aldrich.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

off-white to light brown

溶解性

DMSO: ≥15 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI

1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI key

UBPYILGKFZZVDX-UHFFFAOYSA-N

Gene Information

human ... ABL1(25), HCK(3055), LYN(4067), SRC(6714)

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32