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伐地昔布 [伐地考昔],Valdecoxib;≥98% (HPLC)

别名:4-(5-甲基-3-苯基-4-异恶唑基)苯磺酰胺;4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide

Empirical Formula (Hill Notation): C16H14N2O3S CAS号: 181695-72-7 分子量: 314.36 MDL编号: MFCD00950568 PubChem化学物质编号: 329823753 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0179
CAS号: 181695-72-7
MDL号: MFCD00950568
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$284.38

说明

伐地考昔 (VCX) 是一种二芳基取代的异恶唑化合物。 它由磺酰丙酰胺组成,是帕瑞昔布的代谢物。

Valdecoxib 可用于: 作为成纤维细胞中的环氧合酶-2 (COX-2) 抑制剂,作为质谱分析的分析物,作为超高效液相色谱-串联质谱 (UPLC-MS/MS) 中用于定量的标准品 血浆样品中的伐地考昔

据报道,伐地昔布具有抗炎、镇痛和解热功能。 它作为肝酶细胞色素 P450 2C9(CYP2C9) 和细胞色素 P450 3A4 (CYP3A4) 的底物。
Valdecoxib 是一种非甾体抗炎药 (NSAID),一种环氧合酶-2 (COX-2) 选择性抑制剂。

一般描述

Valdecoxib (VCX) is a diaryl substituted isoxazole compound. It comprises of sulfonyl propanamide and is a metabolite of parecoxib.
 

应用

Valdecoxib may be used: as cyclooxygenase-2 (COX-2) inhibitor in fibroblast cells, as an analyte for mass spectrometry analysis, as an standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quantification of valdecoxib in plasma samples
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

Valdecoxib is reported to elicit anti-inflammatory, analgesic and antipyretic functionality. It acts as a substrate for the liver enzyme cytochrome P450 2C9(CYP2C9) and cytochrome P450 3A4 (CYP3A4).
Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) selective inhibitor.
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to off-white

溶解性

DMSO: >25 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

Cc1onc(-c2ccccc2)c1-c3ccc(cc3)S(N)(=O)=O

InChI

1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)

InChI key

LNPDTQAFDNKSHK-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

 

安全信息

象形图

Health hazardEnvironment

警示用语:

Warning

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16