伏立康唑，Voriconazole；≥98% (HPLC)

图片 伏立康唑，Voriconazole；≥98% (HPLC)
别名：3S-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇；2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496

Empirical Formula (Hill Notation): C16H14F3N5O CAS号: 137234-62-9 分子量: 349.31 MDL编号: MFCD00905717 PubChem化学物质编号: 329823674 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0005
CAS号: 137234-62-9
MDL号: MFCD00905717
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说明

一般描述

Voriconazole is a triazole[1] and a synthetic derivative of fluconazole.[2]
 

应用

Voriconazole has been used:
  • as a control and Erg11 inhibitor in YPD medium[3]
  • as a reference drug to test the activity of essential oils against clinical strains of Candida sp.[4]
  • as an antifungal agent to test its interactions with valproic acid (VPA)[5]
  • to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates[6]

生化/生理作用

伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖性 14-α甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少。
Voriconazole is used to treat invasive aspergillosis (IA).[1] It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.[2]
 

其他说明

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white

溶解性

DMSO: >20 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F

InChI

1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

InChI key

BCEHBSKCWLPMDN-MGPLVRAMSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral

靶器官

Eyes

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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