伊维菌素，Ivermectin；powder

图片 伊维菌素，Ivermectin；powder
别名：依维菌素；22,23-二氢阿维菌素 B1；异阿凡曼菌素；MK-933；22,23-二氢阿巴美丁；22,23-Dihydroavermectin B1

CAS号: 70288-86-7 MDL编号: MFCD00869511 PubChem化学物质编号: 24278497 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: I8898
CAS号: 70288-86-7
MDL号: MFCD00869511
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

伊维菌素是衍生自阿维菌素的大环内酯。它起到抗寄生虫剂的作用。伊维菌素用于治疗胃肠蛔虫，肺虫，螨虫和虱子。它用于治疗盘尾丝虫病，类圆线虫病，蛔虫病和丝虫病。
α7神经元烟碱型乙酰胆碱受体的正变构调节剂；还调节谷氨酸-GABA激活的氯离子通道。

一般描述

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.
 

应用

Ivermectin has been used:
  • in Caenorhabditis elegans fecundity assay
  • in larval development test
  • to measure in vivo topical acaricide activity of compounds in rats
  • to assess its acute and chronic effects to zebrafish
  • in percutaneous drug injection method to treat cystic echinococcosis
  • in liquid chromatography with fluorescence detection method

生化/生理作用

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
 

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

其他说明

Primarily ivermectin B1a.
 
 

属性

形式

powder

质量水平

100

溶解性

MEK: 50 mg/mL

抗生素抗菌谱

parasites

application(s)

agriculture
environmental

作用机制

cell membrane | interferes

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

2-8°C

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576)
mouse ... Abcb1a(18671) , Abcb1b(18669)

 

安全信息

警示用语：

Danger

危险分类

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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