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伊班膦酸钠盐,Ibandronate sodium salt;≥97% (NMR), solid

别名:(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat;(1-羟基-3-(甲基戊基氨基)亚丙基)双膦酸钠

Empirical Formula (Hill Notation): C9H22NNaO7P2 CAS号: 138844-81-2 分子量: 341.21 MDL编号: MFCD07197214 PubChem化学物质编号: 329815388 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I5784
CAS号: 138844-81-2
MDL号: MFCD07197214
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说明

伊班膦酸钠盐已被用于通过产生浓度曲线来研究其对利什曼原虫和贾第鞭毛虫的增殖和超微结构的影响。它还被用于阐明含氮双膦酸盐(N-BPs)进入细胞质并抑制其分子靶标的途径。

伊班膦酸盐是一种含氮双膦酸盐(N-BP)。它潜在地抑制破骨细胞中的甲羟戊酸途径。因此,伊班膦酸盐被有效地用于治疗骨质疏松症和其他骨骼相关疾病。
伊班膦酸钠抑制法呢基二磷酸合酶(IC50 = 20nM)。伊班膦酸钠也是一种骨吸收抑制剂。它已被研究体外抗肿瘤作用,如细胞凋亡诱导、抑制细胞生长、抑制侵入性行为和抑制血管生成,以及其在包括乳腺癌和前列腺癌在内的各种癌症中的体内作用。

应用

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves.[1] It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.[2]
 

生化/生理作用

Ibandronate is a nitrogen-containing bisphosphonate (N-BP).[1] It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.[2]
Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
 

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

测定

≥97% (NMR)

形式

solid

储存条件

protect from light

颜色

white

溶解性

H2O: >10 mg/mL

创始人

Roche

储存温度

2-8°C

SMILES string

[Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI

1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1

InChI key

LXLBEOAZMZAZND-UHFFFAOYSA-M

Gene Information

human ... FDPS(2224)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16