人转铁蛋白，Transferrin human；powder, BioReagent, suitable for cell culture, ≥98%

General description

Transferrin is a glycoprotein with a branched carbohydrate chain, having two sites for ferric ion binding in its polypeptide chain.^[3]

Application

Transferrin human has been used:
• to incubate human proximal tubule cells (HKC) - 8 cells along with IgG for the examination of albumin specificity^[4]
• as a supplement in serum-containing/devoid medium for human thyroid cell culture^[5]
• as a target glycoprotein to develop an in-gel hydrazinolysis method^[6]

Biochem/physiol Actions

Transferrin mediates iron transportation from plasma to cells.^[3] The iron-bound transferrin are of three forms: monoferric A/B transferrin and diferric transferrin.^[3] The transferrin binds to specific cell surface receptors and are internalized by endocytosis.^[1] Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.^[1][2] Transferrin is known to deliver iron to cells in a physiologically safe and effective form.

Other Notes

Partially iron-saturated

Preparation Note

60℃热处理10小时。

Analysis Note

通过琼脂糖电泳纯化。

性质

安全信息