人血清白蛋白 [人白蛋白]，Albumin human [rHSA]；lyophilized powder, Fatty acid free, Globulin free, ≥99% (agarose gel electrophoresis)

General description

Albumin is the most abundant protein in blood plasma, produced in the liver.^[3]

Albumin is a known carrier of fatty acids (FA). Thus control over specific FA′s for cell culture is important, as different cell lines can differ in their sensitivity to particular fatty acids. Fatty acid-free human serum albumin (HSA) is therefore useful for cell culture studies where specific fatty acid content must be strictly controlled, so that researchers can use particular fatty acids specific to their cell lines. Fatty acid-free albumin also allows for optimal and maximum binding sites for using specific fatty acids in cell culture. The use of FA-free HSA also addresses concerns about endogenous FA′s potentially in non-FA-free HSA.

Albumin is the most copious plasma protein in humans.^[5] Albumin turnover is seen in infants with iron deficiency anemia.^[6] Serum albumin is a reliable prognostic indicator in liver disease. Oxidative damage of albumin is associated with advanced liver disease.^[7]

Albumin is widely used as a blocking agent in immunoassays and immunodetection procedures, and as a carrier protein for dilution of antibodies. Awareness of potential trace endogenous content of globulins / IgG in human serum albumin (HSA) is therefore important, because such trace globulins / IgG may serve as antigens for secondary antibodies in immunodetection work. This product undergoes testing for low globulin content / status as essentially globulin-free.

Application

来自人血清的白蛋白已用在葡萄糖溶液中制备糖化人血清白蛋白（gHSA）。^[1]它也已用在研究中评估表面纳米形貌和化学成分对血液相容性的影响。^[4]

白蛋白用于测试其对头孢托仑对耐青霉素的肺炎链球菌的体外杀菌活性的影响。 ^[2] 它已在临床上用于严重和经常危及生命的情况，例如由于外伤、烧伤和手术引起的休克和失血。^[3]它也用于测试非酶糖基化对人血清白蛋白解折叠的影响。^[1]

包装

1, 5, 10 g in poly bottle

100, 500 mg in poly bottle

Biochem/physiol Actions

血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。

Features and Benefits

• Fatty acid-free / low fatty acid content
• Globulin-free / low globulin content

Other Notes

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性质

安全信息