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人血清白蛋白 [人白蛋白],Albumin human [HSA];lyophilized powder, essentially protease free, ≥96% (agarose gel electrophoresis)

别名:人血清蛋白;人白蛋白;白蛋白来源于人;Albagen™;HSA;Human serum albumin;Human albumin

CAS号: 70024-90-7 EC 号: 274-272-6 MDL编号: MFCD00081418 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A4327
CAS号: 70024-90-7
MDL号: MFCD00081418
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¥1,502.90

说明

白蛋白是血浆中最丰富的蛋白质。血清白蛋白产生于肝脏,是脂肪酸、氨基酸和类固醇等生物分子的载体蛋白。用白蛋白测试其对头孢妥仑体外杀菌活性的影响,以对抗青霉素耐药肺炎链球菌。它已被临床用于严重且经常危及生命的情况,如因创伤、烧伤和手术导致的休克和失血。
用于测试非酶糖化对人血清白蛋白去折叠的影响。它还用于测试肠上皮细胞用于HLA II类抗原处理的两种不同途径。

一般描述

Albumin is the most copious protein in blood plasma. Produced in the liver, serum albumin serves as a carrier protein for biomolecules like as fatty acids, amino acids, and steroids.

This human serum albumin (HSA) product has been specially tested and evaluated to be low in the following properties:
  • Essentially protease-free / low protease content
  • Low alkaline phosphatase content
  • Low peroxidase content

Serum albumin is used in various applications related to molecular biology, notably as an inert protein stabilizer for stock solutions of enzymes and proteins of interest. In such applications, it is thus important for the HSA to be protease free, to maintain the integrity of the protein or enzyme of interest.

Protease-free HSA is especially useful for applications like:
  • Enzyme assays
  • Protein-based assays
  • Protease-sensitive techniques such as:
(a) Enzyme immunoassay (EIA)
(b) Nucleic acid hybridization
(c) Radioimmunoassay (RIA)
 

应用

Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia. It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.
It was used to test the effect of non-enzymatic glycation on the unfolding of human serum albumin. It was also used to test the two distinct pathways used by intestinal epithelial cells for HLA class II antigen processing.
 

生化/生理作用

血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白,对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质,特别是药物(例如布洛芬、华法林),并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。
 

特点和优势

  • Low protease activity / essentially protease-free (≤ 0.0001 units/mg protein)
  • Low alkaline phosphatase activity (≤ 0.001 units/mg protein)
  • Low peroxidase activity (≤ 0.001 units/mg protein)

制备说明

Prepared from A1653
 

其他说明

更多信息参见人血清白蛋白
 
 

属性

生物来源

human

质量水平

200

测定

≥96% (agarose gel electrophoresis)

形式

lyophilized powder

分子量

monomer calculated mol wt 66478 Da

technique(s)

tissue culture: suitable

杂质

HIV I and HIVII, HCV and HBsAg, tested negative

溶解性

H2O: soluble 50 mg/mL

UniProt登记号

异质活性

Alkaline phosphatase ≤0.001 units/mg protein
Peroxidase ≤0.001 units/mg protein
Protease ≤0.0001 units/mg protein

储存温度

2-8°C

Gene Information

human ... ALB(213)

 

安全信息

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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