The gene HSP60 (heat shock protein 60) is mapped to human chromosome 2q33.1. It is a mitochondrial protein. HSP60 is induced under various stress conditions, including DNA damage, oxidative stress and heat shock. HSP60 is also referred to as HSPD1 (heat shock protein family D member 1).
HSP60 (heat shock protein) works together with the cochaperonin HSP10 to allow protein folding of mitochondrial-imported proteins. It is involved in brain myelination and pathogenesis of hypomyelinating neurodegenerative disease. It also enhances proinflammatory response in cells, including macrophages, dendritic cells and endothelial cells. Mutation in HSP60 is linked with hereditary spastic paraplegia (SPG13).
Solution in Dulbecco′s buffered saline
|biological source ||human|
|recombinant ||expressed in E. coli|
|assay ||≥95% (SDS-GE)|
|form ||buffered aqueous solution|
|shipped in ||dry ice|
|storage temp. ||−70°C|
|Gene Information ||human ... HSPD1(3329)|
RIDADR NONH for all modes of transport