人类热休克蛋白60，Heat Shock Protein 60 human [HSP 60]；recombinant, expressed in E. coli, buffered aqueous solution, ≥95% (SDS-GE)

General description

The gene HSP60 (heat shock protein 60) is mapped to human chromosome 2q33.1.^[1] It is a mitochondrial protein. HSP60 is induced under various stress conditions, including DNA damage, oxidative stress and heat shock.^[2] HSP60 is also referred to as HSPD1 (heat shock protein family D member 1).

Biochem/physiol Actions

HSP60 (heat shock protein) works together with the cochaperonin HSP10 to allow protein folding of mitochondrial-imported proteins. It is involved in brain myelination and pathogenesis of hypomyelinating neurodegenerative disease.^[3] It also enhances proinflammatory response in cells, including macrophages, dendritic cells and endothelial cells.^[4] Mutation in HSP60 is linked with hereditary spastic paraplegia (SPG13).^[1]

Physical form

Solution in Dulbecco′s buffered saline

性质

安全信息