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五味子酯甲,Schisantherin A;≥98% (HPLC)

Gomisin C, Schizantherin A, Wuweizi ester A;CAS号 58546-56-8 经验分子式(希尔表示法) C30H32O9 分子量 536.57 PubChem Substance ID 329824980 NACRES NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00379
CAS号: 58546-56-8
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¥1,137.73

产品描述

Schisantherin A是从五味子的五味子果实中分离得到的木脂素.Schisantherin A是一种基于机制的抑制剂,可竞争性抑制CYP3A4并使其不可逆地失活。 帕金森氏病等疾病。 它抑制肿瘤的进展,并可能成为癌症治疗的潜在药物靶标。 StA阻断ATP结合盒转运蛋白并恢复癌细胞中抗癌药物的水平。 它还具有抗炎特性。

包装

25 mg in poly bottle

Biochem/physiol Actions

Schisantherin A is a lignan isolated from the fruits of Schisandra chinesi.[1]

Schisantherin A is a mechanism-based inhibitor that competitively inhibits and irreversibly inactivates CYP3A4.[2]
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson’s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment.[4] StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells.[5] It also has anti-inflammatory property.[6]

性质

Quality Level  200
assay  ≥98% (HPLC)
form  powder
storage temp.  −20°C
SMILES string  CC1(O)C(C)CC2=CC(OCO3)=C3C(OC)=C2C4=C(C=C(OC)C(OC)=C4OC)C1OC(C5=CC=CC=C5)=O
InChI  1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3
InChI key  UFCGDBKFOKKVAC-UHFFFAOYSA-N


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16