二氢丹参酮I，Dihydrotanshinone I [DHTS]；≥98% (HPLC)

图片 二氢丹参酮I，Dihydrotanshinone I [DHTS]；≥98% (HPLC)
别名：(-)-二氢丹参酮I；15,16-二氢丹参酮I；(-)-Dihydrotanshinone I；15,16-Dihydrotanshinone I；Dihydrotanshinone I

Empirical Formula (Hill Notation): C18H14O3 CAS号: 87205-99-0 分子量: 278.30 MDL编号: MFCD28016070 PubChem化学物质编号: 329798655 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D0947
CAS号: 87205-99-0
MDL号: MFCD28016070
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说明

一般描述

DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
 

应用

Dihydrotanshinone I (DHTS) has been used:
  • to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
  • as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
  • as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
  • as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
  • as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)

生化/生理作用

Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
 
 

属性

生物来源

Salvia miltiorrhiza

质量水平

200

检测方案

≥98% (HPLC)

形式

powder

储存条件

protect from light

颜色

red

溶解性

ethanol: 1 mg/mL, clear, orange to red

储存温度

2-8°C

SMILES string

C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O

InChI

1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1

InChI key

HARGZZNYNSYSGJ-JTQLQIEISA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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