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丹参酮IIA磺酸钠,Tanshinone II-A sodium sulfonate [TIIAS];≥95%

别名:6,7,8,9,10,11-hexahydro-1,6,6-Trimethyl-10,11-dioxo-phenanthro[1,2-b]furan-2-sulfonic acid sodium salt, Sodium tanshinone IIA sulfonate, Sulfotanshinone sodium II-A, TIIAS

CAS号 69659-80-9 经验分子式(希尔表示法) C19H17NaO6S 分子量 396.39 MDL number MFCD09028094
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2517
CAS号: 69659-80-9
MDL号: MFCD09028094
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥528.44

产品描述

丹参酮II A磺酸盐是丹参酮II A的水溶性衍生物,在肝炎和败血症的啮齿动物模型中显示出抗炎特性。 丹参酮II A磺酸盐靶向Ca2 +激活的钾通道和羧酸酯酶2。最近的研究表明,丹参酮II A磺酸盐而不是丹参酮II A充当人嘌呤能受体P2X7的强负变构调节剂。

Biochem/physiol Actions

Tanshinone II A sulfonate is a water-soluble derivative of tanshinone II A that exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A sulfonate targets Ca2+-activated potassium channels and carboxylesterase 2. Recent studies indicate that tanshinone II A sulfonate but not tanshinone II A acts as potent negative allosteric modulator of the human purinergic receptor P2X7.

性质

assay  ≥95%
form  powder
color  white to beige
solubility  H2O: 2 mg/mL, clear (warmed)
storage temp.  2-8°C
SMILES string  CC1(C)CCCC2=C3C(C(OC(S(=O)(O[Na])=O)=C4C)=C4C(C3=O)=O)=CC=C21
InChI  1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1
InChI key  AZEZEAABTDXEHR-UHFFFAOYSA-M


安全信息

WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16