两性霉素B [来源于链霉菌属]，Amphotericin B from Streptomyces sp；BioReagent, suitable for cell culture, ~80% (HPLC)

General description

Chemical structure: polyene

包装

1, 5 g in glass bottle

250 mg in glass bottle

Application

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

Biochem/physiol Actions

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。

Caution

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.

Preparation Note

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture.

性质

安全信息

符号

  GHS07

信号词 Warning

危害声明 H335

靶器官 Respiratory system

个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

危害码 (欧洲) Xn

风险声明 (欧洲) 22-36/37/38

安全声明 (欧洲) 26

RIDADR NONH for all modes of transport

WGK德国 WGK 3