Chemical structure: polyene
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity,  and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-
• for amphotericin perforated patch technique
• as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay
• as a component of Arcobacter selective isolation broth
1, 5, 100 g in glass bottle
100, 250, 500 mg in glass bottle
Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.