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两性霉素B [来源于链霉菌属],Amphotericin B from Streptomyces sp;~80% (HPLC), powder

Fungizone;CAS号 1397-89-3 经验分子式(希尔表示法) C47H73NO17 分子量 924.08 Beilstein/REAXYS Number 78342 EINECS 编号 215-742-2 MDL number MFCD00877763 PubChem Substance ID 57653841 NACRES NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A4888
CAS号: 1397-89-3
MDL号: MFCD00877763
增值税发票 √ 免费货运 [顺丰 联邦] √
¥1,032.00

产品描述

General description

Chemical structure: polyene

Application

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, [1] and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers [3][2]. It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-
• for amphotericin perforated patch technique[4]
• as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay[5][6][7]
• as a component of Arcobacter selective isolation broth[8]

包装

1, 5, 100 g in glass bottle

100, 250, 500 mg in glass bottle

Biochem/physiol Actions

两性霉素B可与甾醇结合,在膜中形成孔,并导致小分子的泄漏。该产品对真菌和酵母最有效。

Caution

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.

Preparation Note

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.

性质

Quality Level300
biological sourceStreptomyces sp.
assay~80% (HPLC)
formpowder
coloryellow to orange
solubilityDMF: 2-4 mg/mL
DMSO: 30-40 mg/mL
H2O: insoluble
Mode of actioncell membrane | interferes
antibiotic activity spectrumfungi
yeast
storage temp.2-8°C
SMILES stringC[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
InChI1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI keyAPKFDSVGJQXUKY-INPOYWNPSA-N


安全信息

符号
GHS07  GHS07
信号词 Warning
危害声明 H335
靶器官 Respiratory system
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22-36/37/38
安全声明 (欧洲) 26
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55
商品标签