丝裂霉素C来源于头状链霉菌，Mitomycin C from Streptomyces caespitosus；≥970 μg/mg (USP XXIV)

图片 丝裂霉素C来源于头状链霉菌，Mitomycin C from Streptomyces caespitosus；≥970 μg/mg (USP XXIV)
别名: Mitomycin Empirical Formula (Hill Notation): C15H18N4O5 CAS号: 50-07-7 分子量: 334.33 Beilstein: 7231816 EC 号: 200-008-6 MDL编号: MFCD00078109 PubChem化学物质编号: 24896554 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: M0440
CAS号: 50-07-7
MDL号: MFCD00078109
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说明

一般描述

Chemical structure: aziridine
 

应用

Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
 

生化/生理作用

作用机制：该产物是专门针对鸟嘌呤核苷序列5′-CpG-3′的烷基化剂。它通过与DNA共价反应，在DNA互补链之间形成交联来抑制DNA合成。 这种相互作用可防止DNA互补链分离，从而抑制DNA复制。
抗菌谱：丝裂霉素C具有很强的抗肿瘤活性，尤其是对艾氏腹水瘤细胞，对革兰氏阳性和革兰氏阴性细菌具有很强的杀菌作用。
 

注意

Stock solutions should be filter sterilized and stored at 2-8 °C in the dark. Solutions at pH 6-9 can be stored at 0-5 °C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
 

制备说明

Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.
 
 

属性

生物来源

Streptomyces caespitosus

质量水平

100

浓度

≥970 μg/mg (USP XXIV)

颜色

blue-violet

溶解性

H2O: 40 mg/mL, clear to very slightly hazy, colorless
H2O: soluble

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES string

[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险声明

H302 - H351

危险分类

Acute Tox. 4 Oral - Carc. 2

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

监管信息

危险化学品
涉药品监管产品
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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