丙酮酸钠，Sodium pyruvate [SP]；powder, BioXtra, suitable for mouse embryo cell culture, ≥99%

Pyruvate, the end-product of the glycolysis pathway,[1] is the anion of pyruvic acid.

 

Sodium pyruvate has been used:

• as a supplement in Ca²⁺ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation[2]
• as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture[3]
• as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment[4]

细胞将丙酮酸钠作为一种易于获取的碳水化合物来源。此外，它还参与氨基酸代谢并启动Kreb′循环。丙酮酸钠减弱体外氧化应激。 对于大多数细胞培养应用，应将100 mM溶液按1:100比例稀释。 该产品已被认证可用于小鼠胚胎培养。

Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis.[5] Sodium pyruvate might also be a new approach treating lactic acidosis.[6]