General description
Trimethyl orthoformate is a commonly used reagent in organic synthesis for the preparation of useful building blocks.[6][7] It is also used to introduce the protecting group for aldehydes by the preparation of acetals.[8] Acetals can be deprotected back to the aldehyde by using acid catalysts.[9]
Application
原甲酸三甲酯可用于:
• 将磺酸转化为甲酯。[1]
• 将2-酰基环己酮转化为相应的缩醛衍生物。[2]
• 介导各种1,2-二醇与氯化锡(IV)的频哪醇反应,并且不产生水。[3]
• 在无溶剂条件下,以三氟甲碳酸铟为催化剂,通过与胺和叠氮化钠发生三组分缩合反应,合成1-取代-1H-1,2,3,4-四唑。[4]
• 在硫酸存在下,用于胺的N-甲基化反应。[5]包装
1, 2 L in Sure/Seal™
100 mL in Sure/Seal™