三氟乙酸，Trifluoroacetic acid [TFA]；for synthesis, ≥99% (acidimetric)

图片 三氟乙酸，Trifluoroacetic acid [TFA]；for synthesis, ≥99% (acidimetric)
别名：TFA；8082600026；8082600101；8082602501；8082600501；8082601001； 线性分子式: CF3COOH CAS号: 76-05-1 分子量: 114.02 Beilstein: 742035 MDL编号: MFCD00004169 EC索引号: 200-929-3
制造商品牌: 默克 Merck , 色谱科 Supelco , 西格玛 Sigma-Aldrich
货号（SKU）: 8.08260
CAS号: 76-05-1
MDL号: MFCD00004169
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¥481.06

说明

三氟乙酸在有机合成中作为溶剂、催化剂和试剂被广泛使用。它是一种强酸和低沸点试剂。它可以用作各种反应的催化剂，例如重排，官能团脱保护，氧化，还原，缩合，加氢芳基化和三氟甲基化。

一般描述

Trifluoroacetic acid is widely used in organic synthesis as a solvent, catalyst and reagent. It is a strong acid and low boiling point reagent. It can be used as a catalyst for a variety of reactions such as rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.[1]
 

应用

Trifluoroacetic acid can be used as a catalyst
  • In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
  • In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.
Trifluoroacetic acid can also be used
  • In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.

特点和优势

Trifluoroacetic acid can be used as a catalyst due to its
  • High acidity
  • Easy elimination
  • Good solubility in organic solvent and in water.

分析说明

含量测定（酸量法）： ≥ 99.0 %
密度（d 20 °C/4 °C）：1.487 - 1.490
鉴别（IR）：符合检验
 
 

属性

蒸汽密度

3.9 (vs air)

质量水平

200

蒸汽压

97.5 mmHg ( 20 °C)

测定

≥99% (acidimetric)

形式

liquid

折射率

n20/D 1.3 (lit.)

pH值（酸碱度）

1 (10 g/L in H2O)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

溶解性

soluble 10 g/mL

密度

1.489 g/mL at 20 °C (lit.)

储存温度

2-30°C

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

 

安全信息

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险声明

H314 - H332 - H412

危险分类

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

储存分类代码

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

闪点(F)

212.0 °F - Pensky-Martens closed cup

闪点(C)

> 100 °C - Pensky-Martens closed cup

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