LambdaFabSelect 是一种亲和树脂,专为纯化人 lambda Fab 片段而设计,具有高结合能力、纯度和产量。17548201;17548202;17548203
货号(SKU): 17548203
增值税发票 √ 免费送货 √ 订货电话:010-68689484
₹ 3,34,199.15

LambdaFabSelect is an affinity resin designed for the purification of human lambda Fab fragments, with high binding capacity, purity, and yield.

LambdaFabSelect 是一种亲和树脂,设计用于纯化人 lambda Fab 片段,具有高结合能力、纯度和产量。

非哺乳动物衍生产品减少了临床应用 Fab 生产中的监管问题
LambdaFabSelect 是一种亲和树脂,专为纯化人 lambda Fab 片段而设计。配体与轻链的恒定区结合,从而能够以高纯度和高产率高效捕获人抗体片段,例如 Fab。

抗体片段,尤其是 Fab,作为潜在的生物药物越来越受到关注,因为它们比单克隆抗体 (Mab) 具有一些优势。例如,Fab 显示出改善的组织穿透药代动力学,并且可以与传统抗原结合位点无法接近的靶点结合。

该产品是 Cytiva 定制设计树脂计划的一部分。

  • Rigid agarose base matrix allows high flow rates and processing of large sample volumes for increased throughput
  • Non-mammalian derived product reduces regulatory concerns in the production of Fabs for clinical applications

LambdaFabSelect is an affinity resin designed for the purification of human lambda Fab fragments. The ligand binds to the constant region of the light chain enabling an efficient capture step for human antibody fragments such as Fabs with high purity and yield.

Antibody fragments, especially Fabs, are getting increased attention as potential biopharmaceuticals because they have some advantages over monoclonal antibodies (Mabs). For example, Fabs show improved pharmacokinetics for tissue penetration and can bind to targets inaccessible to conventional antigen-binding sites.

The product is a part of Cytiva's Custom Designed resins program.

ParameterLambdaFabSelect, 1 L
Order InformationThis product is part of our Custom Designed Media program and not yet a standard product. If you are interested in large-scale quantities, please contact your local Cytiva representative. 
Chromatography techniqueAntibody affinity chromatography 
BioProcess resinNo 
LigandRecombinant protein (Mr 13 000), produced in S. cerevisiae, with affinity for the constant domain of the immunoglobulin lambda light chain 
Particle size, d50V1~75 µm 
MatrixHighly cross-linked agarose 
Binding Capacity/ml Chromatography Medium2Approximately 20 mg Fab/mL of resin 
Ligand densityApprox. 7 mg/ml of medium 
pH stability, operational33–10 
pH stability, CIP42–12 
Pressure/Flow Specification300 kPa at 600 cm/h, 1 m diameter column, 20 cm bed height 
Storage2 to 8°C, 20% Ethanol 
Chemical stabilityStable to commonly used aqueous buffers: 6 M urea, 6 M guanidine hydrochloride, 70 % ethanol, 30 % isopropanol 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2Dynamic binding capacity at 10% breakthrough measured in a Tricorn 5/50 column, 5 cm bed height, 4 min residence time (75 cm/h) for polyclonal Fab lambda reagent in PBS, pH 7.4.
  • 3pH range where resin can be operated without significant change in function.
  • 4pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16