抗体片段,尤其是 Fab,作为潜在的生物药物越来越受到关注,因为它们比单克隆抗体 (MAb) 具有一些优势,KappaSelect 是一种专为纯化人 Fab (kappa) 片段而设计的亲和树脂。17545803;17545802;17545801
货号(SKU): 17545803
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Antibody fragments, especially Fabs, are getting increased attention as potential biopharmaceuticals because they have some advantages over monoclonal antibodies (MAbs), KappaSelect is an affinity resin designed for the purification of human Fab (kappa) fragments

ParameterKappaSelect, 1 L
Order InformationIf you are interested in large-scale quantities, please contact your local Cytiva representative 
Chromatography techniqueAntibody affinity chromatography 
BioProcess resinYes 
LigandRecombinant protein (M13 000), produced in S. cerevisiae, with affinity for the constant domain of the immunoglobulin kappa light chain 
Particle size, d50V1~75 µm 
MatrixHighly cross-linked agarose 
Ligand Coupling MethodAmide linkage 
Binding Capacity/ml Chromatography Medium2Approximately 15 mg Fab/mL of resin 
Ligand densityApprox. 5 mg/ml of medium 
ApplicationKappaSelect is an affinity chromatography resin designed for the purification of Fab (kappa) with high binding capacity, purity and yield 
pH stability, operational33–10 
pH stability, CIP42–12 
Pressure/Flow Specification300 kPa at 600 cm/h, 1 m diameter column, 20 cm bed height 
Storage2 to 8°C, 20% Ethanol 
Chemical stabilityStable to commonly used aqueous buffers: 6 M urea, 6 M guanidine hydrochloride, 70 % ethanol, 30 % isopropanol 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2Static capacity for polyclonal Fab kappa determined in 1 mL HiTrap column; elution pH 2.5.
  • 3pH range where resin can be operated without significant change in function.
  • 4pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16