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β-烟酰胺腺嘌呤二核苷酸水合物 [氧化型辅酶I]，β-Nicotinamide adenine dinucleotide hydrate [β-NAD, β-DPN]；Grade I, free acid, 100% (dry weight)

别名：NAD，氧化型辅酶I，辅酶1，辅酶A，二磷酸吡啶核苷酸，β-烟酰胺腺嘌呤二核苷酸水合物，β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide

CAS号 53-84-9 经验分子式（希尔表示法） C21H27N7O14P2 · xH2O 分子量 663.43 (anhydrous basis) MDL number MFCD00036253 PubChem Substance ID 329818699

品牌: 罗氏 Roche , 西格玛 Sigma-Aldrich

货号（SKU）: NAD100-RO

CAS号: 53-84-9

MDL号: MFCD00036253

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目录价.SKU-Variant

1g [10127965001]
5g [10127973001] [+¥2,769.30]

¥1,005.98

数量:

产品描述

General description

Nicotinamide adenine dinucleotide (NAD) is a ubiquitously^[5] found electron carrier^[4] and a cofactor. NAD⁺ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD⁺ complexes, the enzyme-cofactor interactions are highly conserved.^[5]

Application

I级NAD（烟酰胺腺嘌呤二核苷酸）用于人类第IV类乙醇脱氢酶的动力学研究。^[3]

NAD has been used in in vitro glycogen synthase kinase 3 (GSK3) deacetylation assay.^[8] It has also been used as a component in assay mix for the determination of kinetic characteristics using an enzyme-linked kinetic assay.^[9]

Biochem/physiol Actions

NAD is also involved in microbial catabolism.^[6] β-NAD acts as a substrate for various enzymes in several cellular processes.^[7]

The NAD (nicotinamide adenine dinucleotide)/NADH ratio regulates the intracellular redox potential, thereby influencing metabolic reactions in vivo.^[1] It works as an electron acceptor.^[2]

电子受体

包装

根据固体质量包装。

Quality

纯度：以干重（酶促、CN-配合物和吸光度）计，100％ β-NAD；A₂₅₀nm - A₂₆₀nm：0.83 ± 0.02，A₂₈₀nm - A₂₆₀nm：0.22 ± 0.02
不含污染物：检测不到LDH抑制剂
有机溶剂： =0.05%（GC）

Specifications

吸光系数：在260 nm处为17.6 x 10³l x mol^-1 x cm^-1 ，333 nm处为5.9 x 10³l x mol^-1 x cm^-1（CN-配合物）

Preparation Note

储存条件（工作液）：在2至8℃下储存4周后，10 mg/ml的水溶液中至少含有99％的NAD

Other Notes

仅用于生命科学研究。不可用于诊断。

本品是普通型 NAD。

性质

assay	100% (dry weight)
form	lyophilized
mol wt	M_r 663.4
packaging	pkg of 1 g (10127965001)
	pkg of 5 g (10127973001)
mfr. no.	Roche
color	off-white
pH	~3.0 (50 mg/mL in water)
λ_max	260 nm
shipped in	wet ice
storage temp.	2-8°C
SMILES string	NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
InChI	1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI key	BAWFJGJZGIEFAR-NNYOXOHSSA-N

安全信息

RIDADR NONH for all modes of transport

WGK德国 WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 88 \| 欧洲Eur. ≥ 126 \| 東京Tokyo ≥ 46 \| 香港与北京 ≥ 62

商品标签

nad (5)
,
dpn (5)

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