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α-糜蛋白酶来源于人类胰腺,α-Chymotrypsin from human pancreas;lyophilized powder, vial of ≥10 BTEE units

别名:胰凝乳蛋白酶;a糜蛋白酶;α-Chymotrypsin from bovine pancreas;

CAS号 9004-07-3 Enzyme Commission (EC) Number 3.4.21.1 ( BRENDA | IUBMB ) EINECS 编号 232-671-2 MDL number MFCD01323069 NACRES NA.54
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C8946
CAS号: 9004-07-3
MDL号: MFCD01323069
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¥6,093.42

产品描述

General description

α-Chymotrypsin belongs to the trypsin family of serine proteases. It is secreted as an inactive precursor chymotrypsinogen to the intestine. The cleavage of peptide bond at amino acid 148 forms α-chymotrypsin.[2] Chymotrypsinogen is encoded by the gene CTRB1 and is mapped to 16q23.1 in the human chromosome.[3]

Application

Human α-chymotrypsin has been used in a study to assess the quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin. Human α-chymotrypsin has also been used in a study to investigate the direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry.

α-Chymotrypsin from human pancreas has been used to test inhibition by N-alkyl isatins against mammalian serine proteases.[1]

Biochem/physiol Actions

A serine protease that hydrolyzes peptide bonds with aromatic or large hydrophobic side chains (Tyr, Trp, Phe, Met) on the carboxyl end of the bond.

Unit Definition

One unit will hydrolyze 1.0 μmole of BTEE per min at pH 7.8 at 25°C.

Analysis Note

由 A1%/280 测定的蛋白质

性质

Quality Level200
formlyophilized powder
mol wt25 kDa
packagingvial of ≥10 BTEE units
storage temp.−20°C
Gene Informationhuman ... CTRB1(1504)


安全信息

符号
信号词 Danger
靶器官 Respiratory system
危害码 (欧洲) Xn
风险声明 (欧洲) 36/37/38-42
安全声明 (欧洲) 22-24-26-36/37
RIDADR NONH for all modes of transport
WGK德国 WGK 1
RTECS GC3050000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16